Targeted treatments for breast cancer

Thursday 25 May 2017, Christie Hospital Manchester

1-day course: Targeted Treatments for Breast Cancer

Level: Intermediate

Description: This study day will describe many different faulty processes that drive the growth and spread of breast cancer. It will also introduce the science behind a plethora of licensed and yet-to-be licensed breast cancer treatments such as HER2-targeted therapies, PARP inhibitors and CDK inhibitors. To set the scene, the science behind standard treatments such as chemotherapy, radiotherapy and hormone therapy will be explained.

Audience: Ideal for research nurses, clinical nurse specialists, administrative staff, clinical trials coordinators

To book, contact: or call: 0161 446 3403


Cancer cell biology & genetics – key concepts:
  • Cells, DNA, chromosomes, genes, proteins
  • Cell division & the cell cycle
  • Causes, types and consequences of DNA damage
  • Drivers of treatment resistance: the cancer microenvironment, genomic instability, intra-umoural heterogeneity
The cellular and molecular makeup of breast cancer
  • How breast cancer develops
  • Faulty genes and proteins that drive breast cancer
  • The role of hormone receptors and HER2
  • Breast cancer stem cells
  • How and why breast cancers spread
The science behind cancer treatments
  • The mechanism of action of chemotherapy and radiotherapy
  • The history of hormone therapies for cancer
  • Targeting cell communication pathways: monoclonal antibodies and kinase inhibitors
Targeted treatments for breast cancer
  • The current landscape of breast cancer treatments
  • Hormone therapies – targeting the oestrogen receptor and aromatase
  • HER2-targeted treatments: trastuzumab, pertuzumab, lapatinib & T-DM1
  • PI3K/AKT/mTOR pathway inhibitors e.g. everolimus , copanlisib, buparlisib
More targeted treatments for breast cancer
  • BRCA genes & PARP inhibitors
  • CDK inhibitors e.g. palbociclib
  • New targets for triple-negative/basal-like breast cancer
  • Immunotherapy for breast cancer